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Monday, May 11, 2020 | History

3 edition of Calcium-activated chloride channels found in the catalog.

Calcium-activated chloride channels

Calcium-activated chloride channels

  • 384 Want to read
  • 3 Currently reading

Published by Academic Press in San Diego, Calif .
Written in English

    Subjects:
  • Chloride channels,
  • Calcium -- Physiological effect

  • Edition Notes

    Includes bibliographical references and index

    Statementedited by Catherine Mary Fuller
    SeriesCurrent topics in membranes -- v. 53
    ContributionsFuller, Catherine Mary
    The Physical Object
    Paginationxxv, 441 p. :
    Number of Pages441
    ID Numbers
    Open LibraryOL17092830M
    ISBN 100121533530

      The calcium-activated chloride channel TMEM16A is a member of a conserved protein family that comprises ion channels and lipid scramblases. Although the structure of the scramblase nhTMEM16 has defined the architecture of the family, it was unknown how a channel has adapted to cope with its distinct functional by:   Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed Cited by:

    calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 25, – (). Key Words: CaCC cystic fibrosis dry mouth intestinal mo-tility drug discovery Calcium-activated Cl channels (CaCCs) are widely expressed in epithelial and nonepithelial cellCited by: At least eight families of chloride channels have been identified as membrane or intracellular chloride channels/binding proteins; they include the ligand-gated chloride channels (e.g., GABAA and glycine), cystic fibrosis transmembrane conductance regulator (), CLC, bestrophins, calcium-activated chloride channel regulator (CLCA), chloride intracellular channel (CLIC), Tweety, and the most.

    separate laboratories discovered that calcium-activated chloride currents are mediated by the TMEM16 (anoctamin) family of proteins in a wide variety of cells, including smooth muscle (2, 4, 29). We have previously demonstrated that the calcium-activated chloride channel TMEM16A is expressed on ASM and plays an important role in ASM contraction. Name: Re-confirmation assay for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) Description: Recent discovery of TMEM16A which encodes a calcium-activated chloride channel (CaCC) has provided a new pathway to identify novel small molecule probes () for this important target.


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Calcium-activated chloride channels Download PDF EPUB FB2

Properties and role of calcium-activated chloride channels in pancreatic duct cells Michael A. Gray, John P. Winpenny, Bernard Verdon, Catherine M. O'Reilly, Barry E. Argent Pages Purchase Calcium-Activated Chloride Channels, Volume 53 - 1st Edition.

Print Book & E-Book. ISBN  Recently the elusive proteins responsible for calcium-activated chloride currents in many cells (TMEM16/anoctamin family) were cloned, which has renewed interest in the field of calcium-activated chloride channels (CaCCs).Cited by: 2.

Calcium-activated chloride channels (CaCCs) play important roles in cellular physiology, including epithelial secretion of electrolytes and water, sensory transduction, regulation of neuronal and cardiac excitability, and regulation of vascular tone.

This review discusses the physiological roles of these channels, their mechanisms of regulation and activation, and the mechanisms of anion. Cl − secretion is age-dependent in CFTR mice, indicating that age-dependent disease may result from an age-dependent induction, activation or regulation of the Cl − channel, which was proposed to be the calcium-activated chloride channel (CaCC).

is a platform for academics to share research papers. calcium-a ctiv a ted chloride channels explains the lack of a lung phenotype in mouse models of cystic fibrosis (94, ).

Giv en that CFTR and CaCCs are both apical Cl. The calcium-activated chloride channel TMEM16A is a ligand-gated anion channel that opens in response to an increase in intracellular Ca 2+ concentration 1,2, protein is Cited by: Calcium activated chloride channels (CaCCs) perform a range of roles in intracellular signalling pathways.

In this review, the potential role of these channels in the myometrium is discussed. Of particular interest is the CaCC forming protein ANO1, which has recently been the subject of detailed investigation within the : Joseph R Dunford, Andrew M Blanks, George Gallos.

The CLCA Family of Calcium-Activated Chloride Channels and Roles in the Eye Stella R. Evans, B.A. A Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree. The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels (CaCCs), are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle ro: IPR Calcium-activated chloride channels (CaCCs) play important roles in cellular physiology, including epithelial secretion of electrolytes and water, sensory transduction, regulation of neuronal and cardiac excitability, and regulation of vascular tone.

This review discusses the physiological roles of these channels, their mechanisms of regulation and activation, and the mechanisms of anion Cited by: Draws together studies on the diverse group of calcium-activated chloride channels (CaCCS) in one comprehensive format.

This work describes the characteristics of CaCCs identified in a number of different systems. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.

ScienceAndré S., Boukhaddaoui H., Campo B., Al-Jumaily M., Mayeux V., Greuet D., Valmier J., Scamps F. Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons. by: Chloride channels activated by intracellular calcium (CaCC) are widely expressed in excitable and non-excitable cells where they perform diverse functions [].The molecular nature of CaCC has been uncertain with both CLCA, TWEETY and BEST genes having been considered as likely candidates [5,9,12].It is now accepted that CLCA expression products are unlikely to form channels per se and probably.

Get this from a library. Calcium-activated chloride channels. [Catherine Mary Fuller;] -- This volume draws together studies on the diverse group of calcium-activated chloride channels (CaCCS) in one comprehensive format. The characteristics of CaCCs identified in a number of different.

This blocker selectivity is more consistent with CFTR than calcium-activated chloride channels (CaCC) (16, 17, 19). Fourth, CFTR inha blocker of CFTR (33), inhibited cholinergically induced airway gland secretion in pigs and in humans without CF but not in humans with CF (48).Cited by: The predominant apical sodium channel is the epithelial sodium channel (ENaC), and chloride conductance is regulated by the CFTR and calcium-activated chloride channels (Figure ).

These channels are subject to precise regulation by environmental stress such as particle deposition or. Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B Article (PDF Available) in The Journal of Physiology (24):n/a-n/a October with Reads How we measure 'reads'.

Calcium-activated Chloride Channels Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin.

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene. This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1pp22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue s: CLCA1, CACC, CACC1, CLCRG1, CaCC .Chloride channels are integral membrane proteins that regulate the movement of chloride ions across cellular membranes.

They perform a vital role in physiological processes such as cell volume. Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and other monovalent anions across cellular membranes in response to Cited by: